Untersuchung zur Auswahl von Eingabeelementen für Großflächendisplays in Flugzeugcockpits

In dieser Arbeit wird die Bedienleistung von Touchscreen und Trackball für Eingaben auf einem Großflächendisplay für die Anwendung in hochagilen Flugzeugen untersucht. Zentraler Punkt der Untersuchung ist die Quantifizierung der Bedienleistung der betrachteten Eingabeelemente Touchscreen und Trackball für die im Flugzeugcockpit herrschende Aufgaben- und Belastungsstruktur. Die Interaktion mit dem Großflächendisplay wurde dabei durch Zeigeaufgaben abgebildet. Die variable Belastungssituation wurde durch verschiedenartige Zusatzaufgaben repräsentiert, die im Versuch simultan mit den Zeigeaufgaben bearbeitet werden mussten. Die Inhalte der unterschiedlichen Aufgaben wurden in einer umfassenden Aufgaben- und Belastungsanalyse am Beispiel eines konkreten Flugzeugmusters ermittelt. Die Flugzeugdynamik und deren Auswirkungen auf die Eingabeleistung des Piloten wurden durch die Analyse vorliegender Flugdaten berücksichtigt. Die Datenerhebung fand ausschließlich mit fliegendem Personal unterschiedlicher Erfahrungsstufen statt, wobei ein Großteil der Versuchspersonen Testpiloten militärischer Flugzeugmuster mit mehr als 3000 Flugstunden sind und daher Expertenstatus besitzen. Die Leistungsunterschiede zwischen den betrachteten Bedienelementen Touchscreen und Trackball sind in den unterschiedlichen Kombinationen aus Zeige- und Zusatzaufgaben erwartungskonform. Die Verwendung des Touchscreens führt, verglichen mit dem Trackball, zu erheblich kürzeren Bedienzeiten bei einem gleichzeitig sehr hohen Erfüllungsgrad der Zeigeaufgabe und wirkt sich darüber hinaus positiv auf die Leistung in der Zusatzaufgabe aus. Zusammenfassend zeigen die Ergebnisse dieser Usability-Untersuchung klare Leistungsdifferenzen in Zeige- und Zusatzaufgaben in Abhängigkeit vom in der Zeigeaufgabe verwendeten Bedienelement. Es ist in den meisten Fällen ein eindeutiger Leistungsvorteil des Touchscreens erwartungskonform für alle Kombinationen aus Zeige- und Zusatzaufgaben erkennbar. Treten bei der gleichzeitigen Bearbeitung Interferenzen zwischen Zeige- und Zusatzaufgabe auf, so führt dies bei der Verwendung des Trackballs zu deutlicheren Leistungseinbußen als beim Touchscreen

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Untersuchung zur Auswahl von Eingabeelementen für Großflächendisplays in Flugzeugcockpits

In dieser Arbeit wird die Bedienleistung von Touchscreen und Trackball für Eingaben auf einem Großflächendisplay für die Anwendung in hochagilen Flugzeugen untersucht. Zentraler Punkt der Untersuchung ist die Quantifizierung der Bedienleistung der betrachteten Eingabeelemente Touchscreen und Trackball für die im Flugzeugcockpit herrschende Aufgaben- und Belastungsstruktur. Die Interaktion mit dem Großflächendisplay wurde dabei durch Zeigeaufgaben abgebildet. Die variable Belastungssituation wurde durch verschiedenartige Zusatzaufgaben repräsentiert, die im Versuch simultan mit den Zeigeaufgaben bearbeitet werden mussten. Die Inhalte der unterschiedlichen Aufgaben wurden in einer umfassenden Aufgaben- und Belastungsanalyse am Beispiel eines konkreten Flugzeugmusters ermittelt. Die Flugzeugdynamik und deren Auswirkungen auf die Eingabeleistung des Piloten wurden durch die Analyse vorliegender Flugdaten berücksichtigt. Die Datenerhebung fand ausschließlich mit fliegendem Personal unterschiedlicher Erfahrungsstufen statt, wobei ein Großteil der Versuchspersonen Testpiloten militärischer Flugzeugmuster mit mehr als 3000 Flugstunden sind und daher Expertenstatus besitzen. Die Leistungsunterschiede zwischen den betrachteten Bedienelementen Touchscreen und Trackball sind in den unterschiedlichen Kombinationen aus Zeige- und Zusatzaufgaben erwartungskonform. Die Verwendung des Touchscreens führt, verglichen mit dem Trackball, zu erheblich kürzeren Bedienzeiten bei einem gleichzeitig sehr hohen Erfüllungsgrad der Zeigeaufgabe und wirkt sich darüber hinaus positiv auf die Leistung in der Zusatzaufgabe aus. Zusammenfassend zeigen die Ergebnisse dieser Usability-Untersuchung klare Leistungsdifferenzen in Zeige- und Zusatzaufgaben in Abhängigkeit vom in der Zeigeaufgabe verwendeten Bedienelement. Es ist in den meisten Fällen ein eindeutiger Leistungsvorteil des Touchscreens erwartungskonform für alle Kombinationen aus Zeige- und Zusatzaufgaben erkennbar. Treten bei der gleichzeitigen Bearbeitung Interferenzen zwischen Zeige- und Zusatzaufgabe auf, so führt dies bei der Verwendung des Trackballs zu deutlicheren Leistungseinbußen als beim Touchscreen

Modeling IP-to-IP Communication using the Weighted Stochastic Block Model

The vision of self-driving networks integrates network measurements with network control. Processing data for each of the tasks comprising network control separately might be prohibitive due to the large volume and waste of computational resources. In this work we make the case of using the Weighted Stochastic Block Model (WSBM), a probabilistic model, to learn a task independent representation. In particular, we consider a case study of real-world IP-to-IP communication. The learned representation provides higher level-features for traffic engineering, anomaly detection, or other tasks, and reduces their computational effort. We find that the WSBM is able to accurately model traffic and structure of communication in the considered trace

First operation of the KATRIN experiment with tritium

The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of β β -decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of 0.2 eV 0.2 eV (90% 90% CL). In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was found and stable conditions over a time period of 13 days could be established. These results are an essential prerequisite for the subsequent neutrino mass measurements with KATRIN in 2019

Global Climate

In 2021, both social and economic activities began to return towards the levels preceding the COVID-19 pandemic for some parts of the globe, with others still experiencing restrictions. Meanwhile, the climate has continued to respond to the ongoing increase in greenhouse gases and resulting warming. La Niña, a phenomenon which tends to depress global temperatures while changing rainfall patterns in many regions, prevailed for all but two months of the year. Despite this, 2021 was one of the six-warmest years on record as measured by global mean surface temperature with an anomaly of between +0.21° and +0.28°C above the 1991–2020 climatology. Lake surface temperatures were their highest on record during 2021. The number of warm days over land also reached a new record high. Exceptional heat waves struck the Pacific Coast of North America, leading to a new Canadian maximum temperature of 49.6°C at Lytton, British Columbia, on 29 June, breaking the previous national record by over 4°C. In Death Valley, California, the peak temperature reached 54.4°C on 9 July, equaling the temperature measured in 2020, and the highest temperature recorded anywhere on the globe since at least the 1930s. Over the Mediterranean, a provisional new European record of 48.8°C was set in Sicily on 11 August. In the atmosphere, the annual mean tropospheric temperature was among the 10 highest on record, while the stratosphere continued to cool. While La Niña was present except for June and July, likely influencing Australia’s coolest year since 2012 and wettest since 2016, other modes of variability played important roles. A negative Indian Ocean dipole event became established during July, associated with a warmer east and cooler west Indian Ocean. Northern Hemisphere winters were affected by a negative phase of the North Atlantic Oscillation at both the beginning and end of 2021. In the Southern Hemisphere, a very strong positive Southern Annular Mode (also known as the Antarctic Oscillation) contributed to New Zealand’s record warm year and to very cold temperatures over Antarctica. Land surface winds continued a slow reversal from the multi-decadal stilling, and over the ocean wind speeds were at their highest in almost a decade. La Niña conditions had a clear influence on the regional patterns of many hydrological variables. Surface specific humidity and total column water vapor over land and ocean were higher than average in almost all datasets. Relative humidity over land reached record or near-record low saturation depending on the dataset, but with mixed signals over the ocean. Satellite measurements showed that 2021 was the third cloudiest in the 19-year record. The story for precipitation was mixed, with just below-average mean precipitation falling over land and below-average mean precipitation falling over the ocean, while extreme precipitation was generally more frequent, but less intense, than average. Differences between means and extremes can be due to several factors, including using different indices, observing periods, climatological base reference periods, and levels of spatial completeness. The sharp increase in global drought area that began in mid-2019 continued in 2021, reaching a peak in August with 32% of global land area experiencing moderate or worse drought, and declining slightly thereafter. Arctic permafrost temperatures continued to rise, reaching record values at many sites, and the thickness of the layer which seasonally thaws and freezes also increased over 2020 values in a number of regions. It was the 34th-consecutive year of mass balance loss for alpine glaciers in mountainous regions, with glaciers on average 25 m thinner than in the late 1970s. And the duration of lake ice in the Northern Hemisphere was the fourth lowest in situ record dating back to 1991. The atmospheric concentrations of the major long-lived greenhouse gases, CO2, CH4, and N2O, all reached levels not seen in at least the last million years and grew at near-record rates in 2021. La Niña conditions did not appear to have any appreciable impact on their growth rates. The growth rate for CH4, of 17 ppb yr−1, was similar to that for 2020 and set yet another record, although the causes for this post-2019 acceleration are unknown presently. Overall, CO2 growth continues to dominate the increase in global radiative forcing, which increased from 3.19 to 3.23 W m−2 (watts per square meter) during the year. In 2021, stratospheric ozone did not exhibit large negative anomalies, especially near the poles, unlike 2020, where large ozone depletions appeared, mainly from dynamical effects. The positive impact of reductions in emissions of ozone depleting substances can be seen most clearly in the upper stratosphere, where such dynamical effects are less pronounced. It was the fourth-lowest fire year since global records began in 2003, though extreme regional fire activity was again seen in North America and also in Siberia; as in 2020, the effects of wildfires in these two regions led to locally large regional positive anomalies in tropospheric aerosol and carbon monoxide abundance. Vegetation is responding to the higher global mean temperatures, with the satellite-derived measures for the Northern Hemisphere for 2021 rated among the earliest starts of the growing season and the latest end of the season on record. The first bloom date for cherry trees in Kyoto, Japan, broke a 600-year record set in 1409. This year we welcome a sidebar on the global distribution of lightning, which has been recently declared an essential climate variable (ECV) by the Global Climate Observing System (GCOS). Time series and anomaly maps from many of the variables described in this chapter can be found in Plates 1.1 and 2.1. As with other chapters, many of the sections have moved from the previous 1981–2010 to the new 1991–2020 climatological reference period, in line with WMO recommendations (see Chapter 1). This is not possible for all datasets, as it is dependent on their length of record or legacy processing methods. While anomalies from the new climatology period are not so easily comparable with previous editions of this report, they more clearly highlight deviations from more recent conditions

State of the climate in 2022: introduction

Earth’s global climate system is vast, complex, and intricately interrelated. Many areas are influenced by global-scale phenomena, including the “triple dip” La Niña conditions that prevailed in the eastern Pacific Ocean nearly continuously from mid-2020 through all of 2022; by regional phenomena such as the positive winter and summer North Atlantic Oscillation that impacted weather in parts the Northern Hemisphere and the negative Indian Ocean dipole that impacted weather in parts of the Southern Hemisphere; and by more localized systems such as high-pressure heat domes that caused extreme heat in different areas of the world. Underlying all these natural short-term variabilities are long-term climate trends due to continuous increases since the beginning of the Industrial Revolution in the atmospheric concentrations of Earth’s major greenhouse gases.In 2022, the annual global average carbon dioxide concentration in the atmosphere rose to 417.1±0.1 ppm, which is 50% greater than the pre-industrial level. Global mean tropospheric methane abundance was 165% higher than its pre-industrial level, and nitrous oxide was 24% higher. All three gases set new record-high atmospheric concentration levels in 2022.Sea-surface temperature patterns in the tropical Pacific characteristic of La Niña and attendant atmospheric patterns tend to mitigate atmospheric heat gain at the global scale, but the annual global surface temperature across land and oceans was still among the six highest in records dating as far back as the mid-1800s. It was the warmest La Niña year on record. Many areas observed record or near-record heat. Europe as a whole observed its second-warmest year on record, with sixteen individual countries observing record warmth at the national scale. Records were shattered across the continent during the summer months as heatwaves plagued the region. On 18 July, 104 stations in France broke their all-time records. One day later, England recorded a temperature of 40°C for the first time ever. China experienced its second-warmest year and warmest summer on record. In the Southern Hemisphere, the average temperature across New Zealand reached a record high for the second year in a row. While Australia’s annual temperature was slightly below the 1991–2020 average, Onslow Airport in Western Australia reached 50.7°C on 13 January, equaling Australia's highest temperature on record.While fewer in number and locations than record-high temperatures, record cold was also observed during the year. Southern Africa had its coldest August on record, with minimum temperatures as much as 5°C below normal over Angola, western Zambia, and northern Namibia. Cold outbreaks in the first half of December led to many record-low daily minimum temperature records in eastern Australia.The effects of rising temperatures and extreme heat were apparent across the Northern Hemisphere, where snow-cover extent by June 2022 was the third smallest in the 56-year record, and the seasonal duration of lake ice cover was the fourth shortest since 1980. More frequent and intense heatwaves contributed to the second-greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Glaciers in the Swiss Alps lost a record 6% of their volume. In South America, the combination of drought and heat left many central Andean glaciers snow free by mid-summer in early 2022; glacial ice has a much lower albedo than snow, leading to accelerated heating of the glacier. Across the global cryosphere, permafrost temperatures continued to reach record highs at many high-latitude and mountain locations.In the high northern latitudes, the annual surface-air temperature across the Arctic was the fifth highest in the 123-year record. The seasonal Arctic minimum sea-ice extent, typically reached in September, was the 11th-smallest in the 43-year record; however, the amount of multiyear ice—ice that survives at least one summer melt season—remaining in the Arctic continued to decline. Since 2012, the Arctic has been nearly devoid of ice more than four years old.In Antarctica, an unusually large amount of snow and ice fell over the continent in 2022 due to several landfalling atmospheric rivers, which contributed to the highest annual surface mass balance, 15% to 16% above the 1991–2020 normal, since the start of two reanalyses records dating to 1980. It was the second-warmest year on record for all five of the long-term staffed weather stations on the Antarctic Peninsula. In East Antarctica, a heatwave event led to a new all-time record-high temperature of −9.4°C—44°C above the March average—on 18 March at Dome C. This was followed by the collapse of the critically unstable Conger Ice Shelf. More than 100 daily low sea-ice extent and sea-ice area records were set in 2022, including two new all-time annual record lows in net sea-ice extent and area in February.Across the world’s oceans, global mean sea level was record high for the 11th consecutive year, reaching 101.2 mm above the 1993 average when satellite altimetry measurements began, an increase of 3.3±0.7 over 2021. Globally-averaged ocean heat content was also record high in 2022, while the global sea-surface temperature was the sixth highest on record, equal with 2018. Approximately 58% of the ocean surface experienced at least one marine heatwave in 2022. In the Bay of Plenty, New Zealand’s longest continuous marine heatwave was recorded.A total of 85 named tropical storms were observed during the Northern and Southern Hemisphere storm seasons, close to the 1991–2020 average of 87. There were three Category 5 tropical cyclones across the globe—two in the western North Pacific and one in the North Atlantic. This was the fewest Category 5 storms globally since 2017. Globally, the accumulated cyclone energy was the lowest since reliable records began in 1981. Regardless, some storms caused massive damage. In the North Atlantic, Hurricane Fiona became the most intense and most destructive tropical or post-tropical cyclone in Atlantic Canada’s history, while major Hurricane Ian killed more than 100 people and became the third costliest disaster in the United States, causing damage estimated at $113 billion U.S. dollars. In the South Indian Ocean, Tropical Cyclone Batsirai dropped 2044 mm of rain at Commerson Crater in Réunion. The storm also impacted Madagascar, where 121 fatalities were reported.As is typical, some areas around the world were notably dry in 2022 and some were notably wet. In August, record high areas of land across the globe (6.2%) were experiencing extreme drought. Overall, 29% of land experienced moderate or worse categories of drought during the year. The largest drought footprint in the contiguous United States since 2012 (63%) was observed in late October. The record-breaking megadrought of central Chile continued in its 13th consecutive year, and 80-year record-low river levels in northern Argentina and Paraguay disrupted fluvial transport. In China, the Yangtze River reached record-low values. Much of equatorial eastern Africa had five consecutive below-normal rainy seasons by the end of 2022, with some areas receiving record-low precipitation totals for the year. This ongoing 2.5-year drought is the most extensive and persistent drought event in decades, and led to crop failure, millions of livestock deaths, water scarcity, and inflated prices for staple food items.In South Asia, Pakistan received around three times its normal volume of monsoon precipitation in August, with some regions receiving up to eight times their expected monthly totals. Resulting floods affected over 30 million people, caused over 1700 fatalities, led to major crop and property losses, and was recorded as one of the world’s costliest natural disasters of all time. Near Rio de Janeiro, Brazil, Petrópolis received 530 mm in 24 hours on 15 February, about 2.5 times the monthly February average, leading to the worst disaster in the city since 1931 with over 230 fatalities.On 14–15 January, the Hunga Tonga-Hunga Ha'apai submarine volcano in the South Pacific erupted multiple times. The injection of water into the atmosphere was unprecedented in both magnitude—far exceeding any previous values in the 17-year satellite record—and altitude as it penetrated into the mesosphere. The amount of water injected into the stratosphere is estimated to be 146±5 Terragrams, or ∼10% of the total amount in the stratosphere. It may take several years for the water plume to dissipate, and it is currently unknown whether this eruption will have any long-term climate effect